After being bitten by a radioactive spider on a school field trip, Peter Parker finds himself gaining spider-like qualities. Adopting the name Spider-Man, Peter first uses his new skills to make money, but when the Green Goblin, another altered super-human, kills Peter's uncle, he swears to use his "spider-skills" to fight evil. Along the way he has to juggle a new job as a local reporter, and a budding romance with a beautiful former-classmate, MJ....

Otto Octavius, reincarnated as "Doc Ock", has kidnapped MJ, and Spider-Man must swing back into action to rescue her.

Peter Parker has finally managed to strike a balance between his devotion to M.J. and his duties as a superhero. But there is a storm brewing on the horizon. When his suit suddenly changes, turning jet black and enhancing his powers, it transforms Peter as well, bringing out the dark, vengeful side of his personality that he struggles to control. Under the influence of the suit, Peter becomes overconfident and starts to neglect the people who care...

Being a patient for the first time changes the life of a surgeon, as he experiences what it's like to be on the other side of a medical chart.